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美国论文代写靠谱吗:姜黄素的药效研究分析

姜黄素是一种多酚,也称为二氟甲烷。它是从姜黄中提取的,姜黄是一种多年生草本植物。考虑到它对包括癌症和阿尔茨海默氏症等其他炎症性疾病在内的许多疾病的疗效水平,这一研究得到了广泛的研究。通过对姜黄素的广泛研究,揭示了姜黄素的一些重要功能。它与许多蛋白质相互作用,抑制几种激酶的表现,并控制转录的激活因子。它们与细胞的存活和增殖有特定的关系。

美国论文代写靠谱吗:姜黄素的药效研究分析

姜黄素虽然具有一定的药效,但由于其疏水性和体内生物利用度低,在临床上的应用有限。然而,由于姜黄素具有多种治疗作用,这些问题的解决一直在探索中。纳米药物的输送系统被认为是克服这些限制的关键。此外,MDR的建立是几种常规化疗失败的关键因素之一。癌细胞对药物产生耐药性的主要机制有三个。这些是:随着水溶性降低药物的摄入量,影响细胞毒性药物如细胞周期移位等性能的细胞内修饰,依赖能量的疏水药物外排增加。

美国论文代写靠谱吗:姜黄素的药效研究分析

Curcumin is a polyphenol, also termed as diferuloylmethane. Its extraction is done from curcuma longa, which is a perennial herb. This has been researched extensively considering its level of therapeutic efficacy for a number of disorders that include other inflammatory diseases such as cancer and Alzheimer’s. On extensively researching curcumin, a number of its significant functions are revealed. It comes in interaction with a number of proteins inhibiting the performance of several kinases and controlling the activated factors of transcription. These have specific involvement in survival and proliferation of cell.

美国论文代写靠谱吗:姜黄素的药效研究分析

Irrespective of the effectiveness delivered by curcumin, it has limited use in the clinic because of its property of hydrophobicity and low level of in vivo bioavailability. However, due to the attribution of several therapeutic activities with curcumin, solution to these issues is being searched persistently. Delivery systems of nano-sized drugs are identified as crucial for overcoming these limitations. In addition, the establishment of MDR is among the crucial factors that fail several conventional chemotherapies. Three main mechanisms are involved by which resistance to drug is acquired by the cancer cells. These are: decreasing the intake of drug with water solubility, intracellular modifications impacting the performance of cytotoxic drugs like shifted cycle of cell, and increased efflux of hydrophobic drugs dependent on energy.